United States securities and exchange commission logo June 25, 2024 Gina Chapman Chief Executive Officer CARGO Therapeutics, Inc. 835 Industrial Road, Suite 400 San Carlos, CA 94070 Re: CARGO Therapeutics, Inc. Registration Statement on Form S-1 Filed June 17, 2024 File No. 333-280249 Dear Gina Chapman: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Jessica Dickerson at 202-551-8013 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Phillip S. Stoup, Esq.